Effect of total sonicated Aggregatibacter actinomycetemcomitans fragments on gingival stem/progenitor cells
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چکیده
منابع مشابه
Azithromycin kills invasive Aggregatibacter actinomycetemcomitans in gingival epithelial cells.
Aggregatibacter actinomycetemcomitans invades periodontal pocket epithelium and is therefore difficult to eliminate by periodontal scaling and root planing. It is susceptible to azithromycin, which is taken up by many types of mammalian cells. This led us to hypothesize that azithromycin accumulation by gingival epithelium could enhance the killing of intraepithelial A. actinomycetemcomitans. [...
متن کاملAzithromycin Kills Invasive Aggregatibacter actinomycetemcomitans in Gingival Epithelial
Address correspondence to: 8 John D. Walters 9 College of Dentistry, The Ohio State University 10 305 West 12th Avenue 11 Columbus, OH 43210 12 Telephone: (614) 292-1169 13 Fax: (614) 292-2438 14 email: [email protected] 15 16 Running Title: Azithromycin Kills Intra-epithelial Aggregatibacter 17
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BACKGROUND An investigation of the mechanisms underlying the production of inflammatory cytokines through the stimulation of microorganisms on gingival epithelial cells may provide insights into the pathogenesis of the initiation of periodontitis. Lipid rafts, microdomains in the cell membrane, include a large number of receptors, and are centrally involved in signal transduction. We herein exa...
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The onset and progressive pathogenesis of periodontal disease is thought to be initiated by the entry of Aggregatibacter actinomycetemcomitans (Aa) into periodontal tissue, especially gingival epithelium. Nonetheless, the mechanism underlying such bacterial entry remains to be clarified. Therefore, this study aimed to investigate the possible role of Aa outer membrane protein 29 kD (Omp29), a h...
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Aggregatibacter actinomycetemcomitans is an oral and systemic pathogen associated with aggressive forms of periodontitis and with endocarditis. Outer membrane vesicles (OMVs) released by this species have been demonstrated to deliver effector proteins such as cytolethal distending toxin (CDT) and leukotoxin (LtxA) into human host cells and to act as triggers of innate immunity upon carriage of ...
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ژورنال
عنوان ژورنال: Medicina Oral Patología Oral y Cirugia Bucal
سال: 2018
ISSN: 1698-6946
DOI: 10.4317/medoral.22661